A dynamic cellular vertex model of growing epithelial tissues 
作者Shao-Zhen Lin; Bo Li; Xi-Qiao Feng
期刊名称Acta Mechanica Sinica
摘要Intercellular interactions play a significant role in a wide diversity of biological functions and processes at both the cellular and tissue scales, e.g., embryogenesis, organogenesis, and cancer invasion. In this paper, a dynamic cellular vertex model is presented to study the morphomechanics of a growing epithelial monolayer. The regulating role of stresses in soft tissue growth is revealed. It is found that the cells originating from the same parent cell in the monolayer can orchestrate into clustering patterns as the tissue grows. Collective cell migration exhibits a feature of spatial correlation across multiple cells. Dynamic intercellular interactions can engender a variety of distinct tissue behaviors in a social context. Uniform cell proliferation may render high and heterogeneous residual compressive stresses, while stress-regulated proliferation can effectively release the stresses, reducing the stress heterogeneity in the tissue. The results highlight the critical role of mechanical factors in the growth and morphogenesis of epithelial tissues, and helps understand the development and invasion of epithelial tumors as well.
关键词Soft tissue; Cellular vertex model; Cell; Morphogenesis

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